- Hypersensitivity to molsidomine;
- shock, collapse;
- severe hypotension (systolic blood pressure less than 100 mm Hg);
- decrease central venous pressure;
- low pressure filling of the left ventricle;
- the acute phase of myocardial infarction;
- the simultaneous testosterone cypionate price use of inhibitors of phosphodiesterase type 5 (PDE 5) -sildenafil, tadalafil, vardenafil – due to the high risk of arterial hypotension;
- age of 18 years (effectiveness and safety have been established).
Precautions : glaucoma (especially the closure); patients with impaired cerebral circulation, with increased intracranial pressure, with a tendency to arterial hypotension in elderly patients after acute myocardial infarction, renal / hepatic failure.
Pregnancy and lactation
The use of molsidomine in pregnant women, especially in the first trimester and during breast-feeding is contraindicated.
Should abandon breastfeeding If necessary, the appointment during lactation.
Dosing and Administration
Tablets dilasidoma should be taken at regular intervals with a sufficient amount of liquid (about 1/2 cup). The tablets can be taken without food.
To prevent strokes typically used 2-4 mg 1-2 times a day.
If necessary, the dose may be increased up to 12-16 mg per day (1 to 4 mg tablet 3-4 times) .
elderly individuals with renal or hepatic insufficiency, as well as with low blood pressure should be applied a lower dose.
Side effect On the part of the cardiovascular system: marked reduction of blood pressure, sometimes to the point of collapse, orthostatic giprtenziya. On the part of the central nervous system: at the beginning of treatment sometimes – headache, testosterone cypionate price rarely – dizziness; slowing of mental and motor reactions (mostly at the beginning of treatment). On the part of the gastrointestinal tract: nausea. Allergic reactions: facial flushing, skin rash (very rare), pruritus, bronchospasm. Very rarely – anaphylactic shock.
Symptoms of overdose are severe headache, marked reduction of blood pressure, tachycardia.
Treatment: in case after receiving a dose of the drug, many times higher than the usual one-time, not been more than an hour – should consider gastric lavage. Moreover, symptomatic treatment should begin.
Interaction with other drugs
When concomitant administration of molsidomine with peripheral vasodilators, blockers “slow” calcium channel blockers, antihypertensives and ethanol enhanced hypotensive effect.
With the simultaneous use of molsidomine with aspirin antiplatelet activity is increasing.
There is a high risk of arterial hypotension with the simultaneous use of phosphodiesterase inhibitors 5 (PDE 5), such as sildenafil, tadalafil, vardenafil.
The combined use. PDE 5 molsidomine contraindicated.
The first dose is prescribed under the control of blood pressure.
Dilasidom not apply for the relief of angina attacks!
In patients at high risk of hypotensive reactions should be an individual approach to the dosage of the drug.
In the acute phase of myocardial infarction Dilasidom can be used only after the stabilization of indicators of blood circulation.
In renal insufficiency molsidomine concentration in plasma does not change.
The product can be combined with other antianginal drugs.
if abnormal liver function, only with the expressed its decline (increase bromsulfaleinovoy samples to 20-50%) increases molsidomine plasma concentration and half-life, which may require adjustments dose.
Taking into account the content of lactose, the drug should not be used in patients with a rare testosterone cypionate price form of congenital intolerance to galactose, deficiency Lapp lactase or malabsorption of glucose-galactose.
at the time of treatment should be deleted reception of ethanol (alcohol).
during treatment (especially at the beginning therapy) should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
tablets 2 mg and 4 mg.
In 30 of the tablets in the blister Al / PVC. 1 blister (1×30) in a cardboard box with instructions for use.
: List B.
Store in a dry, dark place at a temperature of 15 to 25 ° C.
Keep out of reach of children.
Do not use beyond the expiration date printed on the package.
Conditions of supply of pharmacies
by prescription. drostanolone enanthate